Accutane (isotretinoin) is used for the treatment of severe acne that can affect patients of any age and has not responded to other medications. Each capsule must be swallowed whole with a full glass of water. You must never use more than prescribed, as this is not going to make your treatment more efficient. Your health care provider must be notified of any medical conditions you have to be able to prescribe the correct dose of Accutane. The following ones are important to mention: diabetes, asthma, depression, mental illness, history of suicide attempt, high triglyceride levels, osteoporosis, anorexia nervosa, as well as heart or liver disease. Tell your doctor if you think taking Accutane is not beneficial for you, but do not adjust the dose yourself. The following medications must be reported to your doctor before you start taking them (combining with Accutane): phenytoin, demeclocycline, minocycline, methylprednisolone, dexamethasone, vitamin A supplements, tetracycline, medications for seizures, doxycycline, or prednisone. Accutane can interact with some of the drugs mentioned and that may affect the success of your treatment negatively.